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The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to aid manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, given that they also are afflicted by weight-related medical issues such as Tupe2 diabestes, high cholesterol and/or hypertension (hypertension).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder so when an aid to quitting smoking treatment.'Obesity remains a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination with a healthy lifestyle which includes a reduced-calorie exercise and dieting, Contrave provides another treatment selection for chronic weight management for people who are obese or are overweight and possess at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple clinical trials that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular physical activity. Results from a clinical study that enrolled patients without diabetes indicated that patients had an average weight loss of four.1% rather than participants have been given placebos) within a 12- month period, while another study involving patients with diabetes had a normal weight loss of 2% over treatment with placebo at 12 months.

Using two separate drugs to shed pounds can be very effective you will find combinations in front of the FDA now awaiting approval. When dealing with weight-loss and the people that go through it you need to err assisting caution and allow the FDA do its job and demand some investigation be done so the public knows the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to make money and that they would say everything to keep people on their own medications.

Researchers found that participants using this drug for a year, lost weight within a month and have kept the load off through the entire 56 weeks in the study. Contrave is really a combination in the drugs naltrexone and bupropion, which usually reflect a whole new trend of weight-loss drugs that are made up of more than one active ingredient, which can make them far better and safer.

Combo-pilling is the newest fad or even better the newest in the future under scrutiny and therefore it is just more publicly known although in the past, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills has become popular may be the fact that by right now there aren't long term prescription weightloss pills that have been licensed by the FDA aside from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications although some people might of the combinations have been rejected or have yet to be licensed by the FDA.

Seizures certainly are a side effect with Contrave and must not be taken in those with seizure disorders. The drug may also raise blood pressure levels and heart rate, and must not be used in people who have a history of cardiac arrest or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure level and heartbeat and must not be used in patients with uncontrolled high blood pressure levels, in addition to by a person with heart-related and cerebrovascular (circulation dysfunction impacting your brain) disease. Patients using a history of cardiac arrest or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stopping smoking.

--Participating in support groups which help the family in the addict recover (for example Al-Anon or Nar-Anon).

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